Department of Biological Sciences, University of Alaska Anchorage

Miki Ii Lab

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Welcome to our lab!

    Maintenance of genome stability is indispensable for health of cells.  Since DNA is continually damaged, accumulation of DNA damage results in mutations that cause defects in transcription, replication, and cell cycle progression.  Unless the DNA damage is repaired, cells undergo premature aging, cancer, and a variety of genetic diseases.  It is necessary to determine the mechanisms of DNA repair and maintenance of genome stability to solve biological problems in humans.  To avoid cancer formation, proper cell cycle regulation is also essential.
    In order to contribute to human health care, especially cancer and aging research, our research is focused on DNA repair pathways responsible for genome stability and related to human diseases.

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